Synthesis and antiradical/antioxidant activities of caffeic acid phenethyl ester and its related propionic, acetic, and benzoic acid analogues.

Neuroprotective effects of propolis and caffeic acid phenethyl ester (CAPE) on the radiation-injured brain tissue (Neuroprotective effects of propolis and CAPE)

Background: Our purpose was to investigate propolis and its component caffeic acid phenethyl ester (CAPE) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation (IR). Materials and Methods: Fifty-four male albino Sprague-Dawley rats, divided into six groups, were designed as normal control group, cranial irradiation of 5 Gray alone, irradiation plus CAPE, irradi...

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Amiodarone-Induced Pulmonary Fibrosis in Rat

Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable dieases. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In th...

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Amiodarone-Induced Pulmonary Fibrosis in Rat

Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable dieases. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In th...

The Effect of Antioxidant Caffeic Acid Phenethyl Ester (cape) on Some Enzyme Activities in Cisplatin-induced Neurotoxicity in Rats

Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, (1) has been synthesized by esterification of caffeic acid (2). At a concentration of 10 μM, it completely blocks production of reactive oxygen species (ROS) in human neutrophils and the xantine/xantine oxidase system (3). Besides its well-known antioxidant activity (2,4). CAPE inhibits certain enzyme activities such ...

Biotransformation of Underutilized Natural Resource to Valuable Compounds in Ionic Liquid: Enzymatic Synthesis of Caffeic Acid Phenethyl Ester Analogues from Immature Coffee Beans